The series was the debut from Yash Raj and stars R Madhavan, Kay Kay Menon, Babil Khan, Divyenndu Sharma, Sunny Hinduja, Juhi Chawla, Dibyendu Bhattacharya, and others.

The Railway Men is based on the 1984 Bhopal Gas leak that claimed the life of many and left many others severely affected for life.